제목 | [논문] 하상준 교수님_The ratio of peripheral regulatory T cells to Lox-1+ PMN-MDSC… | ||||
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작성자 | 비임파성 장기 면역 연구센터 | 등록일 | 2018-11-13 | 조회수 | 1743 |
The ratio of peripheral regulatory T cells to Lox-1+ PMN-MDSC predicts the early response to anti-PD-1 therapy in non-small cell lung cancer patients
Abstract : Immune checkpoint inhibitors (ICI) have emerged as a promising treatment modality in nonsmall cell lung cancer (NSCLC) patients. However, ICI monotherapy has a relatively low response rate (approximately 20-50% in NSCLC patients) (1), and as a consequence, the development of predictive biomarkers of response are important to inform clinical decisions regarding ICI use. While PD-L1 expression on tumor cells is currently used as a predictive determinant for anti-PD- 1 therapy responses, the accuracy of this test is relatively poor. Therefore, better predictive biomarkers for anti-PD-1 therapy in NSCLC patients are needed. Myeloid derived suppressor cells (MDSC) and regulatory T cells (Treg) play crucial immune suppressive roles in cancer patients (2). In addition to promoting tumor growth, the suppressive actions of MDSC and Treg hinders the efficacy of cancer immunotherapy. Therefore, we hypothesized that frequency of immune suppressive cellular subset might be correlated with the response to anti-PD1 therapy. The fact that MDSC and Treg can be easily detected and affordably quantified in the peripheral blood of NSCLC patients make them excellent candidates for predictive biomarkers to ICI. |