제목 | [논문] 배외식 교수님_Novel Sca-1 + macrophages modulate the pathogenic progress of endotoxemia | ||||
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작성자 | 비임파성 장기 면역 연구센터 | 등록일 | 2021-01-26 | 조회수 | 1072 |
Novel Sca-1 + macrophages modulate the pathogenic progress of endotoxemia
Macrophages are important innate immune cells that play crucial roles in inflammatory responses. Accumulating evidence has demonstrated macrophage heterogeneity based on biomarkers, functions, and localization. Here, we report a novel stem cell antigen-1 (Sca-1)-positive macrophage population induced in the pathological conditions caused by lipopolysaccharide (LPS). Sca-1 is only upregulated in macrophages but not in monocytes and neutrophils upon LPS injection. Sca-1þ macrophages develop from resident peritoneal macrophages. LPS-induced Sca-1þ macrophage generation was partly blocked by antieIFNeg antibody, suggesting a role of IFN-g in the process. LPS-stimulated production of IL-6, TNF-a, and CCL2 is significantly lower in Sca-1þ macrophages compared to their counterpart Sca-1- macrophages. Depletion of Sca-1þ macrophages using anti-Sca-1 antibody significantly increased survival rate and reduced lung and kidney damage in an LPS-induced sepsis model. Taken together, we discovered a novel population of Sca-1þ macrophages in LPS-induced septic conditions. |
이전글 | [논문] 배외식 교수님_Sphingosylphosphorylcholine blocks ovariectomy-induced bone loss by suppressing Ca 2+... |
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다음글 | [논문] 배외식 교수님_Formyl peptide receptors in the mucosal immune system |