학교소개
Dendritic Cell Biology and Immunology
(Left) With Ralph Steinman(2011 Novel prize awardee) at the DC conference in Kobe, Japan.
(Right) Dendritic cells(DCs), discovered by Ralph Steinman, are the most professional antigen presenting cells in our immune system.
PKR as a novel p53-target gene
When the host chromosomes are damaged by genotoxic chemo drugs, PKR plays a key role in p53-mediated tumor suppression. (Yoon et al., PNAS 2009).
When activated by genotoxic chemo drugs, PKR induces cell cycle G2/M arrest by Cdc2 degradation, resulting in tumor suppression (Yoon et al., EMBO report 2010).